And the sixth angel sounded the trumpet: and I heard a voice from the four horns of the great altar, which is before the eyes of God, Saying to the sixth angel, who had the trumpet: Loose the four angels, who are bound in the great river Euphrates. And the four angels were loosed, who were prepared for an hour, and a day, and a month, and a year: for to kill the third part of men.
Revelation 9:13-15